Detailed view for Smp_125910

Basic information

TDR Targets ID: 286849
Schistosoma mansoni, rhogef and pleckstrin domain protein
Source Database / ID:  GeneDB

pI: 6.847 | Length (AA): 1049 | MW (Da): 119640 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169   PH domain
PF00621   RhoGEF domain
PF14604   Variant SH3 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005515   protein binding  
GO:0005089   Rho guanyl-nucleotide exchange factor activity  
GO:0035023   regulation of Rho protein signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
82 141 2o9s (A) 823 880 28.00 0 0.72 0.340097 -0.82
83 142 2fpe (A) 2 59 34.00 0 0.93 0.444097 -1.05
84 141 2fei (A) 3 56 44.00 0 0.93 0.395191 0.02
454 867 2pz1 (A) 226 605 17.00 0 1 0.207562 0.9
478 1038 4h6y (A) 537 1030 45.00 0 1 0.659695 0.23
942 1047 4bbk (A) 371 482 20.00 0 0.86 0.238949 -0.99
944 1036 1upq (A) 58 152 28.00 0 0.95 0.418556 -0.94

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131315)

Species Accession Gene Product
Caenorhabditis elegans CELE_F52D10.6   Protein F52D10.6
Drosophila melanogaster Dmel_CG44193   Chondrocyte-derived ezrin-like domain containing protein ortholog (H. sapiens)
Echinococcus granulosus EgrG_001088000   FERM and pleckstrin domain containing protein
Echinococcus multilocularis EmuJ_001088000   FERM and pleckstrin domain containing protein
Homo sapiens ENSG00000006607   FERM, RhoGEF and pleckstrin domain protein 2
Loa Loa (eye worm) LOAG_07569   hypothetical protein
Mus musculus ENSMUSG00000025555   FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
Mus musculus ENSMUSG00000034066   FERM, RhoGEF and pleckstrin domain protein 2
Schistosoma japonicum Sjp_0303270   FERM, RhoGEF and pleckstrin domain-containing protein 2, putative
Schistosoma mansoni Smp_125910   rhogef and pleckstrin domain protein
Schmidtea mediterranea mk4.018473.02   Putative 4.1 G protein
Schmidtea mediterranea mk4.010626.00  
Schmidtea mediterranea mk4.009841.04   Dab2-interacting protein-like
Schmidtea mediterranea mk4.016303.01   BcDNA.GH03163
Schmidtea mediterranea mk4.026085.00   Putative rhogef and pleckstrin domain protein
Schmidtea mediterranea mk4.001858.02  
Schmidtea mediterranea mk4.000695.01   BcDNA.GH03163
Schmidtea mediterranea mk4.001573.05   Putative 4.1 G protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_125910 (Schistosoma mansoni), rhogef and pleckstrin domain protein
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